Regencell Bioscience Holdings, an early-stage, Hong Kong-based bioscience company with no revenue, is the latest speculative overseas stock to attract an unusual surge in trading demand.
Shares of Regencell, which says it develops traditional Chinese herb treatments to treat childhood attention deficit hyperactivity disorder and autism, more than tripled on Monday — soaring more than 280% by the close. A 38-for-1 split declared on June 2 took effect on Monday.
The company’s year to date performance is off the charts too, having risen 46,000% in 2025. By Monday’s close, Regencell, founded in 2014 and traded on Nasdaq under the ticker ‘RGC’ since 2021, had a total market capitalization of $29.7 billion, according to S&P Capital IQ.
Regencell CEO Yat-Gai Au controls 86.24% of the total number of shares outstanding, according to FactSet data.
Regencell Bioscience Holdings in 2025.
Regencell is the latest example of a speculative international stock attracting attention during summer trading. In August, 2022, for example, AMTD Digital, a Hong Kong-based fintech company, climbed 126%, briefly giving it a market value greater than Coca-Cola and Bank of America.
Earlier this month, Regencell explained the stock split as designed solely “to enhance liquidity in the market for the company’s ordinary shares and make the shares more accessible to investors.” Stock splits do not change anything fundamentally about a company.
Regencell’s surge also came amid an increased focus on alternative medicines after Robert F. Kennedy Jr. was sworn in as Secretary of the U.S. Department of Health and Human Services in February. Kennedy, a vaccine skeptic, has taken steps to discourage routine immunizations in the U.S., last week removing all of the members of a panel that advises the Centers for Disease Control and Prevention on vaccines.
Regencell’s stock often makes huge one-day swings. For example, shares jumped roughly 30% on March 21, before dropping 30% the following trading day.
Obscure treatments, zero revenue
In spite of the wild spike in the stock, little is known about the efficacy and commercialization of the Regencell’s treatments for ADHD and Autistic Spectrum Disorders.
Regencell’s business centers on a proprietary Traditional Chinese Medicine formula (TCM) developed in a partnership with TCM practitioner Sik-Kee Au using his “Sik-Kee Au TCM Brain Theory.” Sik-Kee Au is the father of the Regencell chief executive officer Yat-Gai Au, the company said in a 2022 statement.
Three liquid-based, orally TCM formulae candidates claim to address mild, moderate and severe conditions and only contain natural ingredients such as so-called “detoxication herbs,” blood circulation herbs and digestion herbs.
“These TCM formulae form the basis of our TCM product candidates, which we intend to develop and commercialize for the treatment of ADHD and ASD,” Regencell’s website reads.
In its latest annual report filed last October, Regencell said that it had not generated any revenue, nor filed for any regulatory approvals of its TCM formulas. For the fiscal years ended June 2024 and 2023, Regencell incurred total net losses of $4.36 million and $6.06 million, respectively, according to a 20F filing to the SEC.
“We have not generated revenue from any TCM formulae candidates or applied for any regulatory approvals, nor have distribution capabilities or experience or any granted patents or pending patent applications and may never be profitable,” read the filing.
Regencell has not responded to a CNBC request for comment.
Regencell’s latest patient case study, dated Nov. 15, 2023, said 28 patients were given the treatment over a period of three months in a second efficacy trial and showed an improvement in symptoms of ADHD and ASD, according to the company’s webpage.
In an earlier case, Regencell said in a 2021 news release that it treated a dozen patients with suspected or confirmed Covid-19 cases, using a modified version of Au’s modified proprietary cold and flu TCM formula. What was described as an improvement of Covid conditions led Regencell to form a joint venture with Honor Epic Enterprises Limited in Sept. 2021 to conduct further tests and commercialize the company’s Covid treatment in ASEAN countries, according to the statement.
Online buzz
The stock has attracted little chatter on social media over the past few years. Those comments that have been made suggest both retail trader enthusiasm — and skepticism.
One user on the Reddit page “r/Shortsqueeze” wrote on Monday that Regencell is “trading like a meme coin. Bought a little to see what happens and it dropped 50% right after lol.” Another user said in a post made three months ago, “I scalp RGC everyday for a bit of profit.” The stock jumped 1,360% in May alone.
On LinkedIn in May, one investor said he “can’t stop laughing,” after reading the company description. Another post from a user in the pharmaceutical industry, according to his profile, last week said Regencell has become the “stock to watch” after its spike in May on “no official news or catalysts.” Another LinkedIn user last month commented on Regencell, saying, “China based, low volume and no official news, bizarro.”
Check out the companies making headlines before the bell. Solar stocks — Companies in the space got battered as the Senate’s version of President Trump’s tax bill would phase out renewable energy incentives . Shares of Enphase Energy dropped 20%, while First Solar and Sunrun slid 16% and 36%, respectively. SolarEdge Technologies pulled back 30%. Verve Therapeutics — Shares rallied 77% in the premarket after the gene editing company agreed to be acquired by Eli Lilly for $10.50 per share, a premium of 67.5% on the company’s last close. The deal, which is worth up to $1.3 billion, is expected to close in the third quarter. Eli Lilly shares fell slightly. Roku — The streaming stock popped 2% following an upgrade to a buy rating from hold at Loop Capital Markets. Analyst Alan Gould’s new price target to $100 — up from $80 — implies upside of 22%. Roku gained 10% on Monday after announcing an exclusive partnership with Amazon that would enable advertisers to reach roughly 80 million U.S. households. Microsoft — Shares fell nearly 1% after The Wall Street Journal, citing people familiar, reported tensions between Microsoft and OpenAI over their AI partnership have reached a boiling point. Lennar — Shares of the homebuilder rose 2.5% after revenue for the fiscal second quarter came in stronger than expected. Lennar reported $8.38 billion in revenue, less than the FactSet consensus of $8.18 billion. T-Mobile US — The telecommunication stock fell 4.4% after Bloomberg and Reuters reported that Softbank sold 21.5 million T-Mobile shares in an unregistered, overnight sale for $224 each. SoftBank raised about $4.8 billion, per the reports. — CNBC’s Fred Imbert, Lisa Han, Alex Harring, Sarah Min and Brian Evans contributed reporting.
The Chase Sapphire Lounge at LaGuardia Airport, accessible only to Sapphire Reserve customers.
Benji Stawski / CNBC
JPMorgan Chase is betting that a long list of new perks will keep affluent Americans hooked on its Sapphire Reserve card, despite a hefty bump in its annual fee.
The bank on Tuesday unveiled an update to its premium credit card, which will now carry a $795 annual fee. That is a 45% jump from its previous level and the card issuer’s largest price increase for the Sapphire since its 2016 launch.
But JPMorgan says users will now get more than $2,700 in annual benefits when the updated card launches on June 23. That includes most of its previous benefits, along with new ones tied to how customers earn and spend points on travel and dining.
For instance, the bank is touting a new redemption program that doubles the value of points used for select travel offers and a new $500 annual credit at its collection of hotels and resorts.
There is also a new $300 dining credit at restaurants that are part of the Sapphire Reserve Exclusive Tables network, a $300 credit for purchases at StubHub or Viagogo and free subscriptions to Apple TV+ and Apple Music, worth $250 per year, JPMorgan said.
Customers who spend at least $75,000 annually on their cards unlock other perks, including top-tier status at Southwest Airlines and IHG Hotels and Resorts.
JPMorgan also introduced a new Sapphire Reserve business card with a $795 annual fee and similar perks as the consumer card, along with credits for ZipRecruiter and Google Workspace. That positions the bank squarely against American Express, which has had a business version of its comparable Platinum card for decades.
Upscale ambitions
JPMorgan, the biggest U.S. bank by assets, shook up the card industry with the launch of the Sapphire Reserve almost a decade ago. The bank cribbed from a playbook established by Amex by bundling perks around travel and dining, and later opened its own network of luxurious airport lounges.
But JPMorgan introduced its premium card with signing bonuses and credits that almost made getting one a financial no-brainer, forcing other issuers to boost their card offers in response.
Now, with JPMorgan heading upmarket with the Sapphire Reserve, the bank is at risk of alienating customers who may opt to downgrade to a Sapphire Preferred card or offerings from Amex or Capital One, said senior Bankrate analyst Ted Rossman.
“When the Sapphire Reserve first came out, it was a solid middle-class play that offered champagne travel on a beer budget,” Rossman said. “These premium cards are going more luxury, and I wonder if the $800 fees are becoming too much for some to stomach.”
That could be by design, according to Rossman. Amex and Capital One have had to rein in access to airport lounges because of overcrowding, and some users have complained that their premium cards no longer feel as special.
Whether cards like the Sapphire Reserve still make sense at $795 in annual fees depends on if customers will take advantage of enough of the new perks, Rossman said.
Chase Sapphire Reserve cards.
Courtesy: JP Morgan Chase
Later this year, Amex will introduce updates to its Platinum cards, which currently have a $695 annual fee. Amex will likely also raise its annual fee while adding more perks, Rossman said.
“These high-rate cards are not for everyone, that’s for sure,” said KBW analyst Sanjay Sakhrani.
But Amex and JPMorgan have pursued a subscription-type business model where an ever-rising level of perks make a compelling value proposition for certain customers, he said.
“They feel that it creates a flywheel around keeping people engaged and spending in the system,” Sakhrani said. “Even at $800 in annual fees, I don’t think just anyone can provide the breadth of perks that you get on those cards.”
Billionaire Ken Griffin , founder and CEO of Citadel, said playing defense is not the best strategy in times of turmoil and volatility, and it almost always backfires on investors. “In finance, when you’re playing defense, you’re almost certainly losing,” Griffin said to Citadel’s new class of summer interns Thursday evening. “There’s no other way to put it. Every time a portfolio manager tells me ‘I’m going on defense,’ I’m waiting to watch the red, because that tends to be what happens next.” Griffin, whose hedge fund oversees $66 billion in assets as of June 1, thinks cash would be a better place to hide out than what are often considered “safe trades” in a risk-off environment. “If you are going on defense, just go to cash. Otherwise, you’re just in the ‘safe trades,’ where everyone else has already gone – and the safe trades are often where the losses are,” he said. Investors have been grappling with an extremely turbulent market this year as President Donald Trump’s policies on trade, foreign relations and taxes continue to be unpredictable. Global geopolitical risks have also intensified after Israel’s airstrikes on Iran last week. Conflict between the two nations has stretched into a fourth day . The volatility in oil prices raised new concerns about price pressures , which had just shown signs of easing. The list of worries continue to complicate the Federal Reserve’s direction for interest rates. “We’ve been extraordinarily good over the years at coaching people to be more risk neutral in their behavior. Most humans are risk averse,” Griffin said. “In finance, the closer you are to risk neutral, the more optimal your decision-making is from a profitability perspective.” Citadel’s internship program is highly selective and competitive. More than 108,000 students applied for over 300 positions this year. The firm’s acceptance rate is lower than those of Harvard University and the Massachusetts Institute of Technology . Citadel has been “incredibly successful” at “creating a culture of real risk takers, people who are willing to step up and to occasionally have a bad day, because unless you’re willing to have a bad day, you’re not going to have a great day,” Griffin said.